The omnipresent environmental contaminant perchlorate, an ingredient in jet fuel, is also a primary cause of hypothyroidism, but is almost never tested for by the conventional endocrinologists in their patient evaluations. Whether it should be treated remains controversial. Comp Biochem Physiol C Toxicol Pharmacol 2002, 133:475481. In fact, a 2004 study in subjects with normal thyroid function found that administration of tyrosine leads to a significant reduction in serum TSH and improvement in mood in winter compared with placebo, while the combined synthetic T4-T3 supplement leads to a worsening of mood in summer and no improvement in winter, indicating supporting glandular function is superior to replacement therapy, as well as the role seasonality may play in hormone function and hormone treatment interventions. However, that information will still be included in details such as numbers of replies. [9] [10] [11] Although we should never forget that LT4 is a life-saving thyroid hormone replacement, and that one should not exclude that the pathological reason that leads to the prescription of LT4 could favor the lung cancer development also. I posted it to see what anyone had to add. 1). The study looked at the prevalence of breast, colorectal, gastric and lung cancer in 18 Italian Regions during 2010 and correlated this data with sales of LT4 in 2009, focusing on women aged 30-84. Other research indicating that increased thyroid activity (hyperthyroidism) contributes to lung cancer pathogenesis was presented, including: Recently T4 has been reported as one of the several endogenous factors capable of supporting proliferation of lung cancer cells. I am having a lot of trouble making any sense of this study. Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked. Factors found to be associated with mortality were age, senile dementia, congestive heart failure, chronic renal failure, and a history of cerebrovascular disease. Those with the greatest risk of developing thyroid disorders are women who have a family history of the disease. It's usually based on the results of blood tests. Whereas a patient who had suboptimal thyroid function, but did not have noticeable symptoms, is suddenly given pharmacological doses of synthetic T4 and suddenly experiences the wide range of acute, adverse health effects associated with a now hyperactive and/or increasingly disrupted thyroid, as a result. Just another excuse for keeping us on doses that are too low. People read a study and think that someone like, perhaps me, is saying "it Causes lung cancer. Given the clear role that selenium deficiency plays in preventing the conversion of T4 to the far more biologically active form of thyroid hormone known as triiodothyronine (T3), which can cause an elevation of thyroxine-stimulating hormone (TSH), why call a mineral deficiency-induced decrease in T4 a monolithic disease entity such as hypothyroidism? Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals nor the advice you receive from them. [14] In other words, you can normalize the main clinically measurable parameter associated with low thyroid function, i.e. [9] [10] [11] Although we should never forget that LT4 is a life-saving thyroid hormone replacement, and that one should not exclude that the pathological reason that leads to the prescription of LT4 could favor the lung cancer development also. I invite those interested to read it and perhaps we can have a discussion on this study. Correlation is NOT causation. Thank you for bringing it to our attention. There are many links attached. 2004 Jun;9(2):157-79. The relationship between levothyroxine use and cancer risk is largely underdetermined. El almacenamiento o acceso tcnico es necesario para crear perfiles de usuario para enviar publicidad, o para rastrear al usuario en una web o en varias web con fines de marketing similares. El almacenamiento o acceso tcnico es necesario para la finalidad legtima de almacenar preferencias no solicitadas por el abonado o usuario. The article also stresses that too many people are being given the diagnosis of either hypo or hyperthyroidism. (They noted that this age range corresponds to more than 80% of the consumers of the drug and to about 99% of all malignant cancers). In the United States, autoimmune thyroid disease (Hashimoto thyroiditis) is the most common cause of hypothyroidism, but globally lack of iodine in the diet is the most common cause. BUT, this is the first I have heard of the potential risk of lung cancer in those who take Synthyroid. There is also compelling research indicating that desiccated thyroid extract (Armour thyroid) results in superior clinical outcomes versus the synthetic hormone, especially as concerns improved body weight. [14] In other words, you can 'normalize' the main clinically measurable parameter associated with 'low thyroid function,' i.e. I was sure that the paper had been discussed here shortly after publication in 2013, but cannot find the thread! Patients with incomplete information (n = 127), preexisting hypothyroidism or levothyroxine replacement before initiation of ICI therapy (n = 11), or other factors known to contribute to thyroid dysfunction after immunotherapy (n = 17) were excluded (Fig. Tokushima J Exp Med 1991, 38:2535. In comparison, 62.4% of female and 37% of male . [13] Hollowell JG, Staehling NW, Flanders WD. Marketed as superior to traditional glandular forms extracted from pigs (whose endocrine glands are far more bioidentical than any other animal we know of) due to the dose-to-dose standardization of the so-called active ingredient T4 versus the natural variations in hormone concentrations found in the real thing, which incidentally contains a wide range of additional hormones including T1, T2, T3, all of which are vitally important. Are you sure you want to block this member? [2] Meng R, Tang HY, Westfall J, London D, Cao JH, Mousa SA, Luidens M, Hercbergs A, Davis FB, Davis PJ, et al: Crosstalk between integrin v3 and estrogen receptor- is involved in thyroid hormone-induced proliferation in human lung carcinoma cells. Given the clear role that selenium deficiency plays in preventing the conversion of T4 to the far more biologically active form of thyroid hormone known as triiodothyronine (T3), which can cause an elevation of thyroxine-stimulating hormone (TSH), why call a mineral deficiency-induced decrease in T4 a monolithic disease entity such as "hypothyroidism"? To investigate the magnitude of the possible association between levothyroxine use and cancer risk, this retrospective c Most of the time, doctors tell patients treated with LT4 that any side effects will be temporary and almost ineluctable, and are usually dealt with through dose reduction. [15] Thanh D Hoang, Cara H Olsen, Vinh Q Mai, Patrick W Clyde, Mohamed K M Shakir. Unfortunately, it's quite typical. Privacy Policy. The first blood test typically done to diagnose hypothyroidism measures the level of thyroid-stimulating hormone (TSH) in the blood. However, the study looked at the incrase of ALL lung cancers, not SCLC, so that data does not correlate with this study. [10] Hofer T, Desbaillets I, Hpfl G, Wenger RH, Gassmann M: Characterization of HIFD-1 alpha overexpressing Hela cells and implication for gene therapy. Intuition and Trust: a Personal Journey Through Ancient Pathways, Meditation, Yoga, Grounding & Mindfulness, Levothyroxine and lung cancer in females: the importance of oxidative stress, 2013 announcement by a National Cancer Institute, T-score based definition of osteoporosis and osteopenia, 30-billion dollar a year market in statin drugs, Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). There is also the very real possibility that T4 will not only not properly interact with thyroxine cellular receptors, but will block out what remaining natural levothyroxine the thyroid is still producing (and whose conformational state is far more health-promoting), essentially acting as an endocrine disrupter at the very moment that it is acting as intended as a 'TSH suppressor.' Epub 2013 Mar 28. [1] Hercbergs AH, Ashur-Fabian O, Garfield D: Thyroid hormone and cancer: clinical studies of hypothyroidism in oncology. En 3 minutos recibirs en tu email COMPLETAMENTE GRATIS todo lo que necesitas para aumentar las ventas de tu empresa. May be of interest: Study: Millions Treated for Hypothyroidism At Risk for, Non-small cell lung cancer - Adenocarcinoma, Non-small cell lung cancer - Squamous cell, Top 5 Questions to Ask Your Lung Cancer Doctor, Patient & Caregiver Network Member Resources, Not A Member Yet? But what can be done for patients who are at low rocket fuel, pesticides, fluoride, which induce low thyroid function. Thyroid dysfunction after immune checkpoint inhibitor treatment in a single-center Chinese cohort: a retrospective study I don't think so. [7] Kinoshita S, Sone S, Yamashita T, Tsubura E, Ogura T: Effects of experimental hyperand hypothyroidism on natural defense activities against Lewis lung carcinoma and its spontaneous pulmonary metastases in C57BL/6 mice. weight loss, anorexia). " According to data from the National Health and Nutrition Examination Survey, years 1988-1994, [13] while 0.3% of the American population exhibits overt symptoms of hypothyroidism, 14 times more (4.3%) have so-called 'subclinical' hypothyroidism only detected via blood work. "Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III)". Compression of the trachea, which may be positional, can occur with nodular goiters and thyroid cancer, and the latter can metastasize to the lungs. The authors delved deeper into the reason why oxidative stress taking place during T4 treatment is particularly linked to lung cancer only: The hypothesis could be that in lungs the increase of hypoxia-induced factor (HIF-1) which is determined by T4 can make oxygen much more available, increasing locally the oxidative stress together with a dangerous angiogenesis stimulation. Researchers are currently studying. I have posted the link, so you can see if it has any merit. This is a horrible disease that ravages the body. Thyroid disease is a major public health concern worldwide. Respiratory system Hypothyroidism weakens the respiratory muscles and decreases lung function. They only reappear when I need to fine tune the medication. rocket fuel, pesticides, fluoride, which induce low thyroid function. Compared to patients without hypothyroidism, those with a high TSH level before hospitalization stayed in the hospital 1.2 days longer and had a 49% higher risk of 30-day readmission and a 43% . However, they pointed out that the opposite was actually described, and that hypothyroidism reduces the aggressiveness of some cancers because of the presence of thyroid hormone receptors on cancer cells, and spontaneous hypothyroidism may delay onset or reduce aggressiveness of cancers.[1]. Assessment of oxidative stress and its balance has not been taken into consideration up to now as it should be. The study looked at the prevalence of breast, colorectal, gastric and lung cancer in 18 Italian Regions during 2010 and correlated this data with sales of LT4 in 2009, focusing on women aged 30-84. LOL. MASA Traditional Tortilla Chips by Ancient Crunch, Vitamins, Minerals & Amino Acid Supplements, http://www.greenmedinfo.com/blog/study- ng-cancers, Patients' Perspectives On Refusing Diagnosis Or Treatment For Lung Cancer, Unintended Weight Loss Is The 2nd Highest Risk Factor For Certain Cancers, Stress Causes Genetic Mutations; Cancer Thrives Under Stress, Tetracyclines (and A Few Other Antibiotics) As A Cure For Cancer, Vitamin B May Increase Risk Of Lung Cancer In Men, Study Says, Biggest Study So Far Shows Aspirin Reduces Any Cancer Risk, Methylation Levels Can Predict Breast Cancer Risk, Vitamin A As A Powerful Treatment For Cancer, Screening For Testicular Cancer (a Review), For Many Cancers Early Diagnosis Can Actually Be Deadly, As Altitude Rises, Lung Cancer Rates Fall, The Anti Depression Pills that may Kill Cancer, Holy Grail Blood Test May Detect Cancer Before Tumors Form. If the results show that TSH is high and T-4 is low, then the diagnosis . (31) 3351-3382 | 3351-3272 | 3351-3141 | 3351-3371. location of blind frog ranch associe-se. Or, simply look at what the young-adult,T-score based definition of osteoporosis and osteopeniahas done to convert millions of healthy middle-age and older women into drug-treatable patients, or, what the lipid hypothesis of cardiovascular disease causation has done to create a 30-billion dollar a year market in statin drugs, to fully appreciate the harms of overdiagnosis and overtreatment. Subclinical hypothyroidism is defined by an elevated serum thyroid-stimulating hormone (TSH) level along with a normal free thyroxine (T4) level. ", Orsomeone posts something about, say a diet or supplement and them some people think they are something it "Cures lung cancer.". J Clin Endocrinol Metab. Why not simply call it selenium deficiency? New Cholesterol Drug Guaranteed to Prematurely Kil Beware the Walgreens travel vaccination scam. They then correlated drug sales with cancers, eliminating the contribution of age and smoking for lung cancer risk. I have so many women friends and family members who have recently been diagnosed with hypothyroidism and their doctors put them all on Synthyroid. Nanosized aluminum being sprayed in the atmosphere CDC Admits as Many as 30 Million Americans Could b Why Turmeric May Be the Diseased Liver's Best Friend. is the fiec part of the evangelical alliance; townhomes in avalon park; 8 ft windmill parts; why is my cash and sweep vehicle negative; nordstrom rack return policy worn shoes Or, if fluoride, mercury, or any number of xenobiotic chemicals in the environment requiring selenium-dependent glutathione-mediated detoxification is causing the "low thyroid," why call chemical poisoning "hypothyroidism"? Brit Med J 1978, 1:210212. In an attempt to show causation, the article notes "patients with small cell carcinoma of the lung often present symptoms suggestive of hyperthyroidism (i.e. Eventually, the decline in thyroid hormone production can result in any of the following: Fatigue and sluggishness. Furthermore, the geometric expansion of hypothyroidism cases in the past decade only thinly conceals an agenda to promote the synthetic form of T4 known as levothyroxine sodium (trade name Synthroid), since with each new 'disease' case the patient is converted into a lifelong customer. and our Why not simply call it selenium deficiency? As I am the caregiver for my dad who has Stage IV lung Cancer, I hope more research can be done on this topic soon. At GreenMedInfo.com, we have indexed plenty of peer-reviewed research on over 30 natural substances, including nutrients and minerals, which may help to resolve low thyroid function, and conversely, over 30 unnatural substances, e.g. For a better experience, please enable JavaScript in your browser before proceeding. Whereas a patient who had suboptimal thyroid function, but did not have noticeable symptoms, is suddenly given pharmacological doses of synthetic T4 and suddenly experiences the wide range of acute, adverse health effects associated with a now hyperactive and/or increasingly disrupted thyroid, as a result. You are using an out of date browser. Clin Cancer Res 2011, 30:77. If people do not wish to find out all they can about their disease that is fine too. Once I got on the medication, the symptoms disappeared. [15] [16]There is also the more logical option of support the bodys thyroid-hormone producing capabilities using the thyroxine precursor L-tyrosine, a basic amino acid with a relatively high margin of safety. Now, I will bring it to the attention of my Endocrinologist. Thanks, I am not suggesting I believe in all that I see. The authors expanded on their findings further: "However, the impression we get from our experience in epidemiological studies monitoring[12] is that this drug should be prescribed more cautiously. If you are already a member, please, Levothyroxine and lung cancer in females: the importance of oxidative stress, recent announcement by a National Cancer Institute, T-score based definition of osteoporosis and osteopenia, 30-billion dollar a year market in statin drugs. There is also the very real possibility that T4 will not only not properly interact with thyroxine cellular receptors, but will block out what remaining natural levothyroxine the thyroid is still producing (and whose conformational state is far more health-promoting), essentially acting as an endocrine disrupter at the very moment that it is acting as intended as a TSH suppressor. This T4 blocking/endocrine-disrupting property of the synthetic form would also activate a negative feedback loop within the endocrine system, further suppressing remaining thyroid function, and resulting in the atrophy of the compromised thyroid, a iatrogenic self-fulfilling prophecy if you will. weight loss, anorexia) was made many years ago together with an over production of both T4 and T3. Results indicate that treatment with levothyroxine was linked with significantly increased mortality (hazard ratio = 1.19). It looks at correlations, as if they had any merit on their own. There is evidence T4 makes cancer more agressive, so although it increases the risk of cancer the mortality risk is higher. When a high-risk patient presents with one or more lung nodules, the path ahead and next steps seems obvious. Non-ASPS articles which could be relevant. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. If I can help someone, fine. Even acute bouts of stress and subclinical adrenal insufficiency can cause cyclical downshifts in thyroid function. It may not display this or other websites correctly. by D.ap Tue Feb 21, 2017 10:40 am, Powered by phpBB Forum Software phpBB Limited. According to data from the National Health and Nutrition Examination Survey, years 1988-1994, [13] while 0.3% of the American population exhibits overt symptoms of hypothyroidism, 14 times more (4.3%) have so-called subclinical hypothyroidism only detected via blood work. I have so much to say about this I could write a book. Ultimately, this latest Italian study is bringing to our attention one of what is likely a wide range of unintended, adverse health effects associated with the overdiagnosis and subsequent overtreatment of hypothyroidism, and the underlying failure of the conventional, largely drug-based paradigm to comprehend the causes and real solutions of disease and human suffering. 500+ pages of Natural Medicine Alternatives and Information. But what can be done for patients who are at low Article published in Wakeup-World.Com. Thus, I am monitored carefully. Millions of people who were not only wrongly diagnosed with cancers and subsequently aggressively treated for them with chemotherapy, radiation and surgery, are now being told that they would have been better left undiagnosed and untreated. If it's high, the test is done again, along with a blood test for the thyroid hormone T-4. I have been reading Izabella Wentz. ", That study is like a fishing expedition. Symptoms. video where the doc is talking about the study , i wlll link study and video below.