robert stanton joslin

1 Joslin Pl. Studies in animals and in human tissue from Dr. Stanton’s laboratory have demonstrated that increased levels of glucose (as occurs in diabetes) leads to a decrease in the activity of G6PD in certain cell types and, as a consequence of lower G6PD activity, leads to decreased level of NADPH. Age: 50 AKA: joslin o stanton Joslin Stanton 116 Irvine Turner Blvd, Newark, NJ 07103. Laura Landro and Joslin Diabetes Center Kidney Services Chief Robert Stanton discuss. Robert Stanton, MD, is a researcher, clinician, and teacher. Fax: (617) 309-2467. He graduated from Hahnemann Universtiy - Philadelphia medical school in 1980. Current studies are also focused on elucidating the role of G6PD and associated proteins in the regulation of all aspects of oxidant metabolism in normal physiology and in pathophysiologic conditions. Phone: (617) 732-2477,(617) 732-2400. In addition to caring for people with diabetes and kidney disease, Dr. Stanton also cares for people with any type of kidney disease as well as caring for people with hypertension. From the Kidney and Hypertension Division, Joslin Diabetes Center, Boston, MA. This lack of sufficient NADPH is likely a significant cause of the increased oxidative stress (increased oxidants) seen in diabetes that leads to kidney disease, vascular disease and other complications. Accepted in revised form October 8, 2013. R01DK054380 (STANTON, ROBERT CARL) Feb 1, 2000 - Jul 31, 2005 NIH Glucose 6-P Dehydrogenase and Diabetic Complications ... Stanton RC. The NPI number assigned to this provider is 1073550851. View Robert C. Stanton’s professional profile on … For patients with diabetes, complications associated with increased oxidant damage include diseases of the heart, eye, kidney, nerves, and blood vessels. Joslin Diabetes Center's COVID-19 pandemic hybrid care model allows patients to tailor their care with remote and in-person services, including telehealth visits. Robert C Stanton 1 Affiliation 1 Renal Section, Joslin Diabetes Center, and Harvard Medical School, Boston, MA 02215, USA. He currently practices at Joslin Diabetes Center and is affiliated with Beth Israel Deaconess Medical Center. The mechanisms responsible for the complications are incompletely understood. He has received three Honorary Professorships from Universities in China. Brigham and Women's Hospital, Nephrology, Specialty Training G6PD deficient mice (no diabetes) had signs of kidney damage (increased urine albumin) and small pancreatic islets as compared to control mice. Oregon Health Sciences University; Chief Resident Oregon Health Sciences University, Fellowship Stay informed with the latest in Diabetes Care, Research, and Development. Address correspondence to Robert C. Stanton, MD, Kidney and Hypertension Division, Joslin Diabetes Center, One Joslin Pl, Boston, MA 02215. In addition, there are on-going collaborations on basic and clinical projects with scientists in China. From the Kidney and Hypertension Division, Joslin Diabetes Center, Boston, MA. The principal antioxidant in all cells is the compound NADPH. Fax: (617) 309-2697. Dr. Robert Stanton discusses the uniqueness of care at the Joslin Nephrology Clinic. The principal source of NADPH for the antioxidant system is glucose 6-phosphate dehydrogenase (G6PD), which is the rate-limiting enzyme of the pentose phosphate pathway. A normal result of cellular metabolism is the production of highly reactive forms of oxygen called oxidants. Author information: (1)Harvard Medical School, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA. robert.stanton@joslin.harvard.edu The number of people with diabetic kidney disease continues to increase worldwide despite current treatments. Dr. Stanton's research is focused on an essential enzyme that plays a major role in regulating oxidative stress levels in all cells, glucose 6-phosphate dehydrogenase. Ver la página en español. Dr. Stanton’s laboratory current projects are focused on continuing the elucidation of the basic cellular physiologic roles for G6PD and the mechanisms and consequences associated with the pathophysiologic alterations of G6PD. Glucose‐6‐phosphate dehydrogenase (G6PD) is the rate‐limiting enzyme of the pentose phosphate pathway. Dr. Stanton is an Associate Professor of Medicine at Harvard Medical School where he is … Moreover, scientists thought that G6PD was a classic “housekeeping gene” that was not highly regulated. Joslin Principal Investigator Robert Stanton, M.D., led the research that discovered that high blood glucose levels damage a key enzyme that guards against oxidative stress in insulin-producing cells. A normal result of cellular metabolism is the production of highly reactive forms of oxygen called oxidants. Research revealed that G6PD is regulated by growth factors, glucose level, aldosterone, and many other factors. Robert C. Stanton, MD, Chief of Nephrology, Joslin Diabetes Center, has no relevant financial relationships; Elena Toschi, MD, Staff Physician, Joslin Diabetes Center, has no relevant financial relationships. This article is part of a supplement that was developed with funding from Novo Nordisk. He is an author of many original articles and chapters, and serves both in reviewer and in editorial positions for academic journals. He graduated from Hahnemann University College Of Medicine in 1980. The normal balance of oxidants in cells is maintained by the interaction of processes that produce oxidants and processes that reduce oxidants, called antioxidants. Received May 31, 2013. Beth Israel Deaconess Medical Center Most recently, research from the laboratory has discovered that overexpression of G6PD in aortic endothelial cells that were exposed to high glucose, leads to a restoration of all cellular antioxidant pathways to normal levels and prevents the high glucose-mediated decrease in cell survival. Robert C. Stanton is Former Chief of Nephrology at Joslin Diabetes Center at the Harvard Stem Cell Institute. Experiments with collaborators have determined that decreased G6PD activity leads to lower nitric oxide production and multiple cellular consequences as a result. Main Location. About Dr. Stanton. robert.stanton@joslin.harvard.edu. 1 Joslin Pl Renal Section, Joslin Diabetes Center. 2001. proliferative retinopathy and renal hypertrophy) and cell death are seen in diabetic complications. Oregon Health Sciences University, Residency American Board of Internal Medicine: Internal Medicine and Nephrology. is the Chief of the Kidney and Hypertension Section at Joslin Diabetes Center and is a Principal Investigator in the Section on Vascular Cell Biology. Traditionally researchers have focused on the role of G6PD in lipid metabolism and the role of G6PD in G6PD deficient-associated hemolytic anemia. The principal source of NADPH for the antioxidant system is glucose 6-phosphate dehydrogenase (G6PD), which is the rate-limiting enzyme of the pentose phosphate pathway. Please visit our main COVID-19 page for all this information in both English and Spanish. Robert Stanton Mark Williams Joslin Diabetes Center is dedicated to providing the most exceptional diabetes care in the world and is relentless in pursuit of a cure. Dr. Robert C Stanton - Boston MA, Nephrology at 1 Joslin Pl Renal Section, Joslin Diabetes Center. Traditionally researchers have focused on the role of G6PD in lipid metabolism and the role of G6PD in G6PD deficient-associated hemolytic anemia. Share. Dr. Stanton is also very involved with teaching at all levels (student, resident, fellow, and faculty) at local, national, and international levels. Dr. Robert Stanton, MD is a nephrologist in Boston, Massachusetts. Thus the laboratory studies how G6PD is regulated, the roles and importance of G6PD in cell growth and cell death, and how to alter G6PD activity to design new treatments aimed to treat such diseases as cancer and diabetes. Dr. Robert Stanton, MD is a nephrology specialist in Boston, MA. He has hospital affiliations with Beth Israel Deaconess Medical Center. View info, ratings, reviews, specialties, education history, and … Dr. Stanton has been invited to lecture throughout the United States and throughout the world (including China, India, the Middle East, Europe, and South America). Use of medications to lower urine protein level in patients with diabetic kidney disease. These results demonstrate that increasing G6PD is a very promising goal for treatment of the complications of diabetes. Many scientists think that the roles and regulation of G6PD in physiology and pathophysiology have been well established as the enzyme was first identified 80 years ago. Boston, MA 02215-5306. The normal balance of oxidants in cells is maintained by the interaction of processes that produce oxidants and processes that reduce oxidants, called antioxidants. Each year, Boston Magazine partners with healthcare researcher Castle Connolly Medical Ltd. to create a list of the... Eleven of Joslin's physicians have made Boston Magazine’s 2020 Top Doctors List. Stanton, Robert Carl / Joslin Diabetes Center: $237,596 Publications. Dr. Stanton’s laboratory also collaborates with multiple colleagues at the Joslin Diabetes Center, Harvard Medical School, and University of Minnesota in the USA. He accepts multiple insurance plans. Phone: (617) 309-2477 Dr. Stanton completed a residency at Oregon Health and Science University. Each year, Boston Magazine partners with healthcare researcher Castle Connolly Medical Ltd. to create a list of the... on Joslin Physicians on Boston Magazine's Top Docs List, Role of Glucose Metabolism and Mitochondrial Function in Diabetic Kidney Disease, The Warburg Effect, Lactate, and Nearly a Century of Trying to Cure Cancer, High glucose-induced ubiquitination of G6PD leads to the injury of podocytes, Linagliptin unmasks specific antioxidant pathways protective against albuminuria and kidney hypertrophy in a mouse model of diabetes, Regional differences in brain glucose metabolism determined by imaging mass spectrometry, Maresins: Specialized Proresolving Lipid Mediators and Their Potential Role in Inflammatory-Related Diseases, Associate Professor of Medicine, Harvard Medical School. Stanton RC(1). Stanton, Robert C (2012) Glucose-6-phosphate dehydrogenase, NADPH, and cell survival. 1. DF/HCC members that share similar concepts* with Robert C. Stanton, MD but have yet to coauthor a publication with this researcher. Robert C. Stanton, MD. Dr. Stanton’s laboratory has also determined that G6PD is central to the health of all cells being essential for cell survival. BOSTON – (September 22, 2016) – Robert C. Stanton, M.D., Chief of the Kidney and Hypertension Section and Principal Investigator in the Section on Vascular Cell Biology at Joslin Diabetes Center and Associate Professor of Medicine at Harvard Medical School, received a 2016 Harvard Medical School (HMS) Special Faculty Prize for Sustained Excellence in Teaching. Postdoctoral Research Fellowship; Tufts University Physiology Department with Lewis Cantley, PhD, Board Certification Recent publications have illustrated the central importance of G6PD to cell health and survival. Phone: (617) 309-2400. Dr. Robert Stanton, MD is a Nephrology Specialist in Boston, MA and has over 40 years of experience in the medical field. PMID: 33449215 DOI: … Many other laboratories around the world have used our research to study the role and regulation of G6PD in cancer, diabetes, and other diseases. 1 Joslin Pl Boston, MA 02215. Make an Appointment (617) 732-2400. 1 Joslin Pl. Robert Stanton, MD, is a researcher, clinician, and teacher. These oxidants under physiologic circumstances have important roles in many cellular activities. COVID Testing and Vaccine Education Events, Associate Professor, Medicine, Harvard Medical School, Active Staff, Nephrology, Beth Israel Deaconess Medical Center. Dr. Stanton is board certified in Internal Medicine. Robert Stanton. Dr. Stanton graduated from the Hahnemann University School of Medicine in 1980. Do you want to see a cure for diabetes in your lifetime? Moreover, scientists thought that G6PD was a classic “housekeeping gene” that was not highly regulated. His work is aimed at determining the basic cellular mechanisms responsible for diabetic kidney disease, for the death of pancreatic beta cells, and for cardiovascular disease in people with diabetes. Additionally, discoveries from Dr. Stanton’s laboratory have demonstrated that decreases in G6PD activity lead to impaired function of multiple cellular systems that depend on NADPH and ultimately cell death. Robert C. Stanton, M.D. Projects in the laboratory are aimed at understanding the specific cellular and molecular mechanisms that lead to impaired G6PD enzyme activity and to determine how to prevent this impairment with a goal of developing treatments for the prevention and treatment of diabetic kidney disease, diabetic vascular disease, and for preserving pancreatic beta cell mass. Research from the kidney and Hypertension Division, Joslin Diabetes Center, Boston, MA and in. 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